The reference site for PROPOXYPHENE

Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects.

WHAT IS PROPOXYPHENE?

Propoxyphene is used to treat moderate to severe pain.

It is an opioid analgesic (related to opium) similar to methadone. The use of opium is at least 2300 years old. In 1806, the first alkaloid of opium was isolated by Serturner. He called it morphine, after the Greek god of dreams, Morpheus. Codeine was identified in 1832. Propoxyphene is half to two-thirds as potent as codeine, meaning that 90 to 120 mg of propoxyphene provides as much pain relief as 60 mg of codeine. This is comparable to the pain relief achieved by 600 mg of aspirin.

Opioid analgesics, including propoxyphene, reduce pain by blocking the receptors in the brain that are involved in the perception (sensing) of pain. Because combinations of opioids (such as propoxyphene or codeine) and either aspirin or acetaminophen produce additive pain relieving effects, they are often found in combination in several drugs.

 

Brand Name(s): Darvon; Darvon-N; PC-CAP; E-Lor; Wygesic
CAS nº: 469-62-5
(proe pox’ i feen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to propoxyphene and its correct use. Please read them carefully.

FDA Information

Propoxyphene was approved by the FDA in 1957.

Why is this medication prescribed?

Propoxyphene is used to treat moderate to severe pain.

It is an opioid analgesic (related to opium) similar to methadone. The use of opium is at least 2300 years old. In 1806, the first alkaloid of opium was isolated by Serturner. He called it morphine, after the Greek god of dreams, Morpheus. Codeine was identified in 1832. Propoxyphene is half to two-thirds as potent as codeine, meaning that 90 to 120 mg of propoxyphene provides as much pain relief as 60 mg of codeine. This is comparable to the pain relief achieved by 600 mg of aspirin.

Opioid analgesics, including propoxyphene, reduce pain by blocking the receptors in the brain that are involved in the perception (sensing) of pain. Because combinations of opioids (such as propoxyphene or codeine) and either aspirin or acetaminophen produce additive pain relieving effects, they are often found in combination in drugs.

Other uses for this medicine

It can be used to ease pain before, during and after an operation.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Propoxyphene comes as a tablet, capsule, and liquid to take by mouth. It is usually taken every 4 hours as needed.

The usual dosage is 65 mg of propoxyphene hydrochloride every 4 hours as needed for pain. The maximum recommended dose of propoxyphene hydrochloride is 390 mg/day.

Take propoxyphene exactly as directed by your doctor.

If you take the liquid form of the medicine, shake the liquid well before each use.

Take each dose with a full glass of water.

Take propoxyphene with food or milk if it upsets your stomach.

Do not stop taking propoxyphene suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.

Increase the amount of fiber and water (six to eight full glasses daily) in your diet to prevent constipation. Do not share this medication with anyone else.

This medicine can become dangerous if not taken properly.

What special precautions should I follow?

BEFORE TAKING PROPOXYPHENE:

Tell your doctor and pharmacist if you are allergic to propoxyphene or any other drugs.

Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other pain relievers; anticoagulants (‘blood-thinners’) such as warfarin (Coumadin); antidepressants; antihistamines; medications for cough, cold, or allergies; muscle relaxants; sedatives; seizure medications; sleeping pills; tranquilizers; and vitamins.

Inform your doctor if you have or have ever had liver or kidney disease, or a history of alcoholism.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking propoxyphene, call your doctor.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking propoxyphene.

You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.

Remember that alcohol can add to the drowsiness caused by this drug.

What should I do if I forget a dose?

Propoxyphene is usually taken when needed. If your doctor has told you to take propoxyphene regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Side effects from propoxyphene are common:

dizziness
sleepy
nausea
vomiting

Tell your doctor if any of these symptoms are severe or do not go away:

dizziness
lightheadedness
drowsiness
upset stomach
vomiting
constipation
stomach pain
skin rash
mood changes
headache

If you experience the following symptom, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives)
seizures
cold, clammy skin
unconsciousness
severe weakness or dizziness

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

slow breathing
seizures
dizziness
weakness
loss of consciousness
coma
confusion
tiredness
cold and clammy skin
small pupils

Product Images

PICTURES OF PROPOXYPHENE PILLS

Below you will find images and specific information on the principal types of propoxyphene that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PROPOXYPHENE HCL
Strength(s): 65 MG
Imprint: 93 741
Manufacturer: TEVA USA

Name: PROPOXYPHENE HCL
Strength(s): 65 MG
Imprint: West-Ward 235
Manufacturer: WEST-WARD

Name: DARVON-N
Strength(s): 100 MG
Imprint: Lilly DARVON-N 100
Manufacturer: ELI LILLY & CO.

Name: DARVON-N
Strength(s): 100 MG
Imprint: DARVON-N 100
Manufacturer: XANODYNE PHARM.

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